brhejoThe BRICS Health JournalThe BRICS Health Journal3034-47003034-4719Sechenov University10.47093/3034-4700.2025.2.3.41-59brhejo-55Research ArticleСтатьиFive years of the Genomas Brasil Program: advancing genomics and precision health within Brazil’s unified health systemhttps://orcid.org/0000-0002-7530-2017Araújo de FrançaGiovanny Vinícius

Giovanny Vinícius Araújo de França, PhD, Technologist, Department of Science and Technology of the Secretariat for Science,Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil, SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775

 

giovanny.franca@saude.gov.brhttps://orcid.org/0000-0001-6231-891XLupatiniEvandro de Oliveira

Evandro de Oliveira Lupatini, PhD, Technologist, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil, SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775

https://orcid.org/0000-0001-5624-8644RochaRodrigo Theodoro

Rodrigo Theodoro Rocha, MSc, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil, SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

 

https://orcid.org/0009-0007-3393-6242ToledoRafaela de Cesare Parmezan

Rafaela de Cesare Parmezan Toledo, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

https://orcid.org/0000-0002-4416-0183FigueiredoGraziella Santana Feitosa

Graziella Santana Feitosa Figueiredo, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

https://orcid.org/0009-0009-6616-7421GonçalvesCarlos Eduardo Ibaldo

Carlos Eduardo Ibaldo Gonçalves, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health,

Asa Norte, Brasília, Federal District, 70655-775 

https://orcid.org/0000-0003-0051-9307MachadoIsis Laynne de Oliveira

Isis Laynne de Oliveira Machado, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

https://orcid.org/0000-0002-1080-1480AnzolinAna Paula

Ana Paula Anzolin, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

 

https://orcid.org/0000-0002-8021-5081GontijoCarolina Carvalho

Carolina Carvalho Gontijo, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

 

https://orcid.org/0009-0003-4742-9808VidalJulia Freitas Daltro

Julia Freitas Daltro Vidal, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

 

https://orcid.org/0000-0003-4917-4469RibeiroAndréa Leite

Andréa Leite Ribeiro, PhD, Technical Consultant, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

https://orcid.org/0009-0001-5788-5917FreitasMeiruze Sousa

Meiruze Sousa Freitas, Specialist in Health Regulation and Sanitary Surveillance, Director, Department of Science and Technology of the Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil; SRTVN PO700 – Ministry of Health

Asa Norte, Brasília, Federal District, 70655-775 

https://orcid.org/0000-0002-3197-5156De NegriFernanda

Fernanda De Negri, PhD, Secretary, Secretariat for Science, Technology, and Innovation in Health, Ministry of Health, Brasília, Federal District, Brazil

Esplanade of Ministries, Block “G”, 8th floor, CEP: 70058-900 

202523122025234159Copyright © Araújo de França G., Lupatini E., Rocha R., Toledo R., Figueiredo G., Gonçalves C., Machado I., Anzolin A., Gontijo C., Vidal J., Ribeiro A., Freitas M., De Negri F., 20252025Araújo de França G., Lupatini E., Rocha R., Toledo R., Figueiredo G., Gonçalves C., Machado I., Anzolin A., Gontijo C., Vidal J., Ribeiro A., Freitas M., De Negri F.Araújo de França G., Lupatini E., Rocha R., Toledo R., Figueiredo G., Gonçalves C., Machado I., Anzolin A., Gontijo C., Vidal J., Ribeiro A., Freitas M., De Negri F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bricshealthjournal.com/jour/article/view/55

This study aimed to assess the implementation of the Brazilian National Program for Genomics and Precision Public Health (GenBR) over its initial five years, identifying key achievements, challenges, and lessons for integrating genomics into public health systems in low- and middle-income countries (LMICs). Established by Ministerial Ordinance GM/MS No. 1,949 on August 4, 2020, GenBR aims to lay the foundation for genomics and precision health within Brazil’s Unified Health System. Its primary goals include advancing science and technology countrywide, fostering the development of a national genomics industry, and conducting proof-ofconcept studies to assess the practical application of precision health in public healthcare. By August 2025, over 250 research projects had been funded in 19 of the country’s 27 federative units, across a range of areas, including oncological, rare, cardiovascular, infectious, neurological, and non-communicable diseases, as well as population genomics and precision health. Financial investments had exceeded BRL 1 billion, funding the sequencing of 67,000 samples. Nine large-scale genomics research projects associated with the Program have contributed to generating whole-genome data from 45,910 individuals. Moreover, four public calls have selected 209 research projects led by science and technology institutions located across all regions of Brazil. GenBR offers key lessons for LMICs seeking to implement genomics in public health, particularly in contexts marked by population diversity, infrastructure asymmetries, and fiscal constraints. Findings highlight the importance of sustained political commitment, inclusive governance, and long-term planning for building national genomic capacity and advancing health equity.

genomicsprecision medicineBrazilnational health programsdatabasesgeneticethicsresearchThe authors acknowledge the support of the Brazilian Ministry of Health, particularly the Secretariat for Science, Technology and Innovation in Health (SCTIE/MS), for the conception, coordination, and ongoing implementation of the Genomas Brasil Program. The authors also thank the National Council for Scientific and Technological Development (CNPq) for its critical role in funding research and infrastructure essential to the advancement of genomics and precision health in Brazil. The authors extend their deep appreciation to the partner institutions—universities, research institutes, public laboratories, biobanks, and health services—that contribute technical expertise, scientific knowledge, and operational capacity across all regions of the country. The authors also thank the collaborating researchers, healthcare professionals, and local health authorities whose engagement and commitment have been instrumental to the program’s success. The authors express special gratitude to the communities and individuals who voluntarily participate in the research and contribute their biological samples and clinical data. Their trust and involvement form the foundation of Genomas Brasil’s mission to promote equitable, population-representative genomic science. 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The authors declare that there are no conflicts of interest present.