Development of approaches for evaluating the pharmacokinetics of meropenem during endolymphatic antibiotic treatment in critically ill patients

Abstract

The use of conventional methods of drug administration during antibiotic therapy of critically ill patients may be insufficient since the MIC required for effective therapy may not be maintained for the required amount of time due to the peculiarities of the patients' pharmacokinetics. Endolymphatic therapy has been proposed as an alternative approach. This article presents information on the evaluation of pharmacokinetics during endolymphatic antibiotic therapy, as well as the obtained comparative pharmacokinetic data compared to intravenous administration.